Tirzepatide Titration Schedule: 2.5mg to 15mg Explained

Tirzepatide is escalated slowly to let receptors adjust. Jumping straight to a high dose causes nausea, fatigue and lost weeks of consistency. This is the standard UK research titration.

The full schedule

Weeks	Weekly dose	Notes
1–4	2.5 mg	Starter dose. Side effects, if any, settle quickly.
5–8	5 mg	First "active" dose. Appetite suppression usually clear.
9–12	7.5 mg	Optional step; many researchers skip if 5 mg is working.
13–16	10 mg	Standard maintenance for most.
17–20	12.5 mg	Upper-mid range.
21+	15 mg	Maximum studied dose.

Titration rules

Never skip more than one level at a time.
Hold a dose for an extra month if side effects are present.
Reduce by one level (not zero) if side effects become intolerable.
Inject the same day each week — Saturday morning is popular for UK buyers because side effects, if any, fall over the weekend.

Injection sites

Subcutaneous: abdomen, upper thigh, back of the upper arm. Rotate sites weekly.

Frequently asked questions

How long should I stay on each dose?

A minimum of 4 weeks. Longer is fine if it is working.

What if I miss a week?

Resume at the same dose if the gap is under 2 weeks. Drop one level if longer.

Can I stop at 5 mg?

Yes — many researchers maintain at 5 mg or 7.5 mg if the effect is sufficient.

Where do I get tirzepatide?

Our tirzepatide page stocks every vial size with UK next-day delivery.

This guide is provided for informational purposes by Next Day Pharma. All peptides supplied are FOR RECONSTITUTION. Always consult a qualified healthcare professional before use.

Peptide catalogue

Melanotan II — £40.00 — 10mg of Melanotan II
Somatropin (HGH) — £60.00 — Somatropin (Human Growth Hormone)
Cagrilintide 10mg — £60.00 — 10mg of Cagrilintide
Epitathlon — £50.00 — 10mg of Epitathlon
PT-141 10mg — £40.00 — 10mg of PT-141
SLU-332 5mg — £65.00 — 5mg of SLU-332
CJC + Ipamorelin — £55.00 — 5mg CJC-1295 + 5mg Ipamorelin
5 Amino 1MQ 50mg — £60.00 — 50mg of 5 Amino 1MQ
SS-31 10mg — £40.00 — 10mg of SS-31
Semax 10mg — £40.00 — 10mg of Semax
Selank 10mg — £40.00 — 10mg of Selank
Ipamorelin 10mg — £40.00 — 10mg of Ipamorelin
Wolverine — £75.00 — 10mg of Wolverine
MOTS-C 20mg — £80.00 — 20mg of MOTS-C
Tesamorelin 20mg — £110.00 — 20mg of Tesamorelin
NAD+ 1000mg — £125.00 — 1000mg of NAD+
GLO 70mg — £70.00 — 70mg of GLO
KLOW 80mg — £90.00 — 80mg of KLOW
BPC-157 10mg — £40.00 — 10mg of BPC-157
TB500 10mg — £50.00 — 10mg of TB500
Retatrutide — £200.00 — Retatrutide
Tirzepatide — £180.00 — Tirzepatide
MT2 10mg (NEXT DAY TAN) — £50.00 — 10mg of Melanotan2
GHK-CU 100mg — £60.00 — 100mg of GHK-CU

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Where to buy Retatrutide in the UK — Supplier checklist, real pricing, pens vs powder, dosing and next-day tracked delivery.
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